中国修复重建外科杂志

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蛋白质因子在调控骨改建过程中的作用机制研究进展

李菊 1,2 , 郭晓东 1,2 , 李明政 1,2,3 , 肖宇 1,2 , , 包崇云 1,3 ,

1. 四川大学口腔疾病研究国家重点实验室（成都 610041） ;
2. 国家口腔疾病临床医学研究中心（成都 610041） ;
3. 四川大学华西口腔医院口腔颌面外科（成都 610041）

收稿日期: 2018-08-11;  修回日期:2018-12-03; 

基金项目: “十三五”国家重点研发计划（2016YFC1102702）；国家自然科学基金资助项目（81701027）；华西口腔医院青年研究基金（WCHS-201612）

通讯作者: 肖宇, Email: xiaoyu_8528@163.com 包崇云, Email: cybao9933@sina.com

Research progress in the mechanism of protein factors in regulating bone remodeling

LI Ju 1,2 , GUO Xiaodong 1,2 , LI Mingzheng 1,2,3 , XIAO Yu 1,2 , , BAO Chongyun 1,3 ,

1. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu Sichuan, 610041, P.R.China ;
2. National Clinical Research Center of Oral Diseases, Sichuan University, Chengdu Sichuan, 610041, P.R.China ;
3. Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu Sichuan, 610041, P.R.China

Corresponding Author: XIAO Yu, Email: xiaoyu_8528@163.com BAO Chongyun, Email: cybao9933@sina.com

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目的 综述蛋白质因子在骨改建过程中的作用及机制，为进一步阐明骨相关疾病的发病机制及临床治疗提供理论依据。 方法 广泛查阅国内外近年相关研究成果，并加以分析、归纳和总结。 结果 骨改建是维持骨稳态的重要生理过程，蛋白作为骨改建过程中的重要刺激因子，调控着骨吸收与骨形成之间的平衡。 结论 目前对于蛋白在骨改建过程中的作用机制研究还不够充分，因此需要进一步深入研究相关蛋白在骨改建过程中的具体作用时间、作用过程以及蛋白质因子间相互作用网络，并确证其在骨改建中的作用机制，为骨相关疾病发病机制的揭示及治疗奠定基础。

Objective To review the role and mechanism of protein factors in bone remodeling, and provides theoretical basis for further elucidating the pathogenesis and clinical treatment of bone-related diseases. Methods The relevant research results at home and abroad in recent years were extensively consulted, analyzed, and summarized. Results Bone remodeling is an important physiological process to maintain bone homeostasis. Protein, as an important stimulator in bone remodeling, regulates the balance between bone resorption and bone formation. Conclusion At present, the research on the mechanism of protein in bone remodeling is insufficient. Therefore, it is necessary to further study the specific time, process, and interaction network of protein in bone remodeling, and to confirm its mechanism in bone remodeling, so as to reveal and treat the pathogenesis of bone-related diseases.

关键词: 骨改建; 蛋白质; 成骨细胞; 破骨细胞

Key words: Bone remodeling; proteins; osteoblast; osteoclast

引用本文： 李菊, 郭晓东, 李明政, 肖宇, 包崇云. 蛋白质因子在调控骨改建过程中的作用机制研究进展. 中国修复重建外科杂志, 2019, 33(1): 115-123. doi: 10.7507/1002-1892.201808059 复制

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