中国修复重建外科杂志

中国修复重建外科杂志

镍钛三维记忆合金网复合自体骨治疗犬胫骨平台塌陷骨折模型生物力学试验

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目的通过将镍钛三维记忆合金网用于体外犬胫骨平台塌陷骨折模型并行生物力学试验,评价其生物学效能,为进一步动物体内实验奠定基础。方法取 8 只成年比格犬共 16 个胫骨平台标本,其中 12 个标本制备胫骨平台塌陷骨折(Schatzker Ⅲ型)模型后随机分为 A、B、C 组,每组 4 个;剩余 4 个正常胫骨平台标本作为空白对照组(D 组)。A、B 组分别于骨缺损处植入镍钛三维记忆合金网复合自体骨和自体骨,外侧钢板螺钉固定;C 组骨缺损处不植骨,外侧直接行钢板螺钉固定。使用 INSTRON-8874 生物力学测试系统由股骨髁上方垂直向下连续加载递增负荷(0~1 700 N),记录最大失效载荷,根据载荷-位移曲线计算刚度。结果A、B、C、D 组最大失效载荷分别为(1 624.72±7.02)、(1 506.57±3.37)、(1 102.00±1.83)、(1 767.64±24.56)N,刚度分别为(129.72±20.83)、(96.54±27.05)、(74.96±17.70)、(169.01±35.62)N/mm,A 组最大失效载荷及刚度显著高于 B、C 组,但显著低于 D 组,差异均有统计学意义(P<0.05)。结论镍钛三维记忆合金网复合自体骨修复犬 Schatzker Ⅲ型胫骨平台塌陷骨折,比单纯自体骨具有更好的生物力学性能。

ObjectiveTo evaluate the biomechanical effect of a nickel-titanium (Ni-Ti) three-dimensional memory alloy mesh in treating a canine tibial plateau collapse fracture model and to lay a foundation for further experiments in vivo.MethodsSixteen tibial plateau specimens of 8 adult Beagle dogs were harvested. Twelve specimens were taken to prepare canine tibial plateau collapse fracture models (Schatzker type Ⅲ) and randomly divided into groups A, B, and C, with 4 specimens in each group. Four normal tibia specimens were used as blank control group (group D). In groups A and B, the bone defects were repaired with Ni-Ti three-dimensional shape memory alloy mesh combined with autologous bone and simple autologous bone respectively, and fixed with the lateral plate and screw. In group C, the bone defect was directly fixed with the lateral plate and screw. By using a biomechanical tester, a progressive load (0-1 700 N) was loaded vertically above the femoral condyle. The maximum failure load was recorded and the stiffness was calculated according to the load-displacement curve.ResultsThe maximum failure loads in groups A, B, C, and D were (1 624.72±7.02), (1 506.57±3.37), (1 102.00±1.83), and (1 767.64±24.56) N, respectively; and the stiffnesses were (129.72±20.83), (96.54±27.05), (74.96±17.70), and (169.01±35.62) N/mm, respectively. The maximum failure load and stiffness in group A were significantly higher than those in groups B and C, but which were significantly lower than those in group D (P<0.05).ConclusionNi-Ti three-dimensional memory alloy mesh combined with autologous bone can repair the Schatzker type Ⅲ tibial plateau collapse fracture, which has better biomechanical properties than simple autologous bone grafting.

关键词: 镍钛合金; 三维记忆合金网; 胫骨平台骨折; 生物力学;

Key words: Nickel-titanium alloy; three-dimensional memory alloy mesh; tibial plateau fracture; biomechanics; dog

引用本文: 晏兆魁, 梁羽, 方跃, 姚相雨, 马坤龙, 黄富国. 镍钛三维记忆合金网复合自体骨治疗犬胫骨平台塌陷骨折模型生物力学试验. 中国修复重建外科杂志, 2018, 32(6): 722-725. doi: 10.7507/1002-1892.201709068 复制

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