目的对近年来血小板反应蛋白(thrombospondins,TSPs)在中枢神经系统(central nervous system,CNS)突触形成中的作用及机制进行综述。方法广泛查阅近年来与 TSPs 在 CNS 突触形成中有关的国内外文献,对 TSPs 结构特征、在 CNS 疾病中的作用及发生机制进行综述。结果TSPs 作为一种寡聚糖蛋白,在血管生成、炎症、成骨、细胞增殖和细胞凋亡等方面具有重要作用。在神经系统中,TSPs 与电压依赖性钙通道、神经连接蛋白以及其他细胞外基质蛋白和细胞表面受体结合,参与和调节 CNS 中突触的形成、成熟以及功能等多个过程。结论TSPs 作为一种寡聚细胞外基质蛋白,在突触形成、CNS 损伤后突触修复等方面发挥重要作用。

ObjectiveTo review the recent progress in the role of thrombospondins (TSPs) in synapse formation in the central nervous system (CNS).MethodsA wide range of domestic and foreign literature on the role of TSPs in the synapse formation of the CNS was reviewed. The role of TSPs in structural features, molecules, and related diseases was reviewed.ResultsAs an oligosaccharide protein, TSPs play important roles in angiogenesis, inflammation, osteogenesis, cell proliferation, and apoptosis. In the nervous system, they bind to voltage-dependent calcium channels, neuronectin, and other extracellular matrix proteins and cell surface receptors, and participate in and regulate multiple processes such as synapse formation, maturation, and function in the CNS.ConclusionTSPs as an oligomeric extracellular matrix protein play an important role in the formation of synapses and the repair of synapses after CNS injury.

关键词: 血小板反应蛋白; 突触; 电压依赖性钙通道; 神经连接蛋白

Key words: Thrombospondins; synapse; voltage-dependent calcium channel; neuroligin

引用本文: 巩朝阳, 向高, 刘开鑫, 张海鸿. 血小板反应蛋白在突触形成中的作用及机制研究进展. 中国修复重建外科杂志, 2019, 33(1): 124-128. doi: 10.7507/1002-1892.201809006 复制

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