中国修复重建外科杂志

中国修复重建外科杂志

尿源性干细胞在骨骼肌肉系统再生领域应用的研究进展

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目的 总结尿源性干细胞(urine derived stem cells,USCs)在骨骼肌肉系统再生领域的应用。 方法 查阅国内外近年来有关 USCs 在骨骼肌肉系统再生领域的相关文献,并进行综合分析。 结果 USCs 取材无创,来源广泛,表达 MSCs 表面标记,具备稳定的增殖能力、多向分化潜能,被广泛应用于骨、皮肤、神经等骨骼肌肉系统的再生领域并展现了一定修复能力。 结论 无创来源 USCs 在骨骼肌肉系统再生领域具备良好的应用前景,但其修复的生物学机制尚需进一步研究。

Objective To review the application of urine derived stem cells (USCs) in regeneration of musculoskeletal system. Methods The original literature about USCs in the regeneration of musculoskeletal system was extensively reviewed and analyzed. Results The source of USCs is noninvasive and extensive. USCs express MSCs surface markers with stable proliferative and multi-directional differentiation capabilities, and are widely used in bone, skin, nerve, and other skeletal and muscle system regeneration fields and show a certain repair capacity. Conclusion USCs from non-invasive sources have a wide application prospect in the regeneration of musculoskeletal system, but the definite biological mechanism of its repair needs further study.

关键词: 尿源性干细胞; 组织工程; 多向分化; 诱导多能干细胞; 骨修复

Key words: Urine derived stem cells; tissue engineering; multi-differentiation; induced pluripotent stem cells; bone repair

引用本文: 邢飞, 刘国明, 段鑫, 项舟. 尿源性干细胞在骨骼肌肉系统再生领域应用的研究进展. 中国修复重建外科杂志, 2018, 32(11): 1477-1482. doi: 10.7507/1002-1892.201804024 复制

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