中国修复重建外科杂志

中国修复重建外科杂志

鱼胶原蛋白作为新型生物医用材料的研究进展

查看全文

目的 总结鱼胶原蛋白作为新型生物医用材料的最新研究进展,讨论该类材料替代哺乳动物源性胶原蛋白用于医学临床的可行性及风险管理。 方法 基于对鱼胶原蛋白在生物医学领域研究最新进展的广泛调研,综合分析其研发、应用现况,提出应重点关注的关键问题。 结果 鱼胶原蛋白来源丰富、病毒传播风险低、生物风险低、宗教壁垒低、生物相容性高,有望作为新型胶原蛋白来源部分替代目前常用的哺乳动物源性胶原蛋白制品应用于临床。但目前我国在该领域的转化医学研究尚处于起步阶段。 结论 鱼胶原蛋白在转化医学领域的应用具有良好的临床可行性和必要性,可部分替代生物风险高的哺乳动物源性胶原蛋白医用制品,但尚需进行大量的应用基础研究。

Objective To review the lately new progress of fish collagen as biomedical materials, and then analyze feasibility and risk management of its application as a substitute of collagen originated from mammals in clinical practice. Methods Based on extensive research on new application and investigation of fish collagen, the paper was prepared to bring comprehensive analysis of its research and application status, and then several key points were focused on. Results Fish collagen has been proved to be a novel collagen of rich source, low risk of virus transmission, low biological risk, less religious barrier, and high biocompatibility. Fish collagen has promising prospect when applied in clinical practice as novel collagen especially as a substitute of collagen derived from mammals. However, very few related translational medicine research of fish collagen has been reported up to now in China. Conclusion As a novel potential substitute of collagen source derived from mammals, fish collagen is concerned to be clinical feasible and necessary in translational medicine. However, massive applied basic researches should be focused on in the further investigations.

关键词: 鱼胶原蛋白; 生物医用材料; 研究进展

Key words: Fish collagen; biomedical material; research progress

登录后 ,请手动点击刷新查看全文内容。 没有账号,
1. Song E, Yeon KS, Chun T, et al. Collagen scaffolds derived from a marine source and their biocompatibility. Biomaterials, 2006, 27(15): 2951-2961.
2. Matsumoto R, Uemura T, Xu Z, et al. Rapid oriented fibril formation of fish scale collagen facilitates early osteoblastic differentiation of human mesenchymal stem cells. J Biomed Mater Res A, 2015, 103(8): 2531-2539.
3. Pal P, Srivas PK, Dadhich P, et al. Accelerating full thickness wound healing using collagen sponge of mrigal fish (Cirrhinus cirrhosus) scale origin. Int J Biol Macromol, 2016, 93(Pt B): 1507-1518.
4. 曾名勇, 张联英, 刘尊英, 等. 几种鱼皮胶原蛋白的理化特性及其影响因素. 中国海洋大学学报 (自然科学版), 2005, 35(4): 608-612.
5. Gauza-Włodarczyk M, Kubisz L, Mielcarek S, et al. Comparison of thermal properties of fish collagen and bovine collagen in the temperature range 298-670K. Mater Sci Eng C Mater Biol Appl, 2017, 80: 468-471.
6. 朱伟, 张晓莉, 刘洋, 等. 鱼鳞胶原蛋白对免疫低下小鼠皮肤伤口愈合的影响. 哈尔滨医科大学学报, 2014, 48(3): 177-181.
7. Muthukumar T, Prabu P, Ghosh K, et al. Fish scale collagen sponge incorporated with Macrotyloma uniflorum plant extract as a possible wound/burn dressing material. Colloids Surf B Biointerfaces, 2014, 113: 207-212.
8. 王茵, 黄煜, 林彩平, 等. 鱼鳞胶原复合止血海绵的制备及其效果的验证. 福建农业学报, 2013, 28(4): 315-319.
9. Mitra T, Manna PJ, Raja STK, et al. Curcumin loaded nano graphene oxide reinforced fish scale collagen—a 3D scaffold biomaterial for wound healing applications. RSC Advances, 2015, 5(119): 98653-98665.
10. Liu C, Liu X, Xue Y, et al. Hydrolyzed tilapia fish collagen modulates the biological behavior of macrophages under inflammatory conditions. Rsc Advances, 2015, 5(39): 30727-30736.
11. Mredha M, Kitamura N, Nonoyama T, et al. Anisotropic tough double network hydrogel from fish collagen and its spontaneous in vivo bonding to bone. Biomaterials, 2017, 132: 85-95.
12. Zhou T, Liu X, Sui B, et al. Development of fish collagen/bioactive glass/chitosan composite nanofibers as a GTR/GBR membrane for inducing periodontal tissue regeneration. Biomed Mater, 2017, 12(5): 055004.
13. Li Q, Mu L, Zhang F, et al. A novel fish collagen scaffold as dural substitute. Mater Sci Eng C Mater Biol Appl, 2017, 80: 346-351.
14. van Essen TH, Lin CC, Hussain AK, et al. A fish scale-derived collagen matrix as artificial cornea in rats: properties and potential. Invest Ophthalmol Vis Sci, 2013, 54(5): 3224-3233.
15. van Essen TH, van Zijl L, Possemiers T, et al. Biocompatibility of a fish scale-derived artificial cornea: Cytotoxicity, cellular adhesion and phenotype, and in vivo immunogenicity. Biomaterials, 2016, 81: 36-45.
16. Park JY, Choi JC, Shim JH, et al. A comparative study on collagen type Ⅰ and hyaluronic acid dependent cell behavior for osteochondral tissue bioprinting. Biofabrication, 2014, 6(3): 035004.
17. Liu CZ, Xia ZD, Han ZW, et al. Novel 3D collagen scaffolds fabricated by indirect printing technique for tissue engineering. J Biomed Mater Res B Appl Biomater, 2008, 85(2): 519-528.
18. Cao H, Chen MM, Liu Y, et al. Fish collagen-based scaffold containing PLGA microspheres for controlled growth factor delivery in skin tissue engineering. Colloids Surf B Biointerfaces, 2015, 136: 1098-106.
19. 张明, 杨玲, 吕辉华, 等. 鱼胶原基缓释材料的制备及其对罗丹明 B 的负载/缓释性能分析. 功能材料, 2017, 48(3): 3193-3201.
20. Yamamoto K, Igawa K, Sugimoto K, et al. Biological safety of fish (tilapia) collagen. Biomed Res Int, 2014, 2014: 630757.