中国修复重建外科杂志

中国修复重建外科杂志

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多孔钽在骨组织工程中的研究进展

丁孝权 , 刘兴旺 , 陈俊 , 陈世益

复旦大学附属华山医院运动医学与关节镜外科（上海 200040）

收稿日期: 2017-11-08;  修回日期:2018-03-26; 

基金项目: 国家重点研发计划项目（2016YFC1100304）

通讯作者: 陈世益, Email: cshiyi@163.com

Research progress of porous tantalum in bone tissue engineering

DING Xiaoquan , LIU Xingwang , CHEN Jun , CHEN Shiyi

Department of Sports Medicine and Arthroscopy, Huashan Hospital, Fudan University, Shanghai, 200040, P.R.China

Corresponding Author: CHEN Shiyi, Email: cshiyi@163.com

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目的 对多孔钽在骨组织工程中的研究进展作一综述。 方法 查阅近年多孔钽在制备、细胞生物学、表面修饰等领域的基础研究文献，并总结分析。 结果 多孔钽自身特有的理化性质赋予其良好的组织相容性、骨整合能力，并可诱导软骨、肌腱修复再生。目前因多孔钽制备条件苛刻、成本较高等因素，限制了其临床广泛应用；新的制备方法及表面修饰技术的发展，为拓展多孔钽的应用范围，优化其骨组织修复再生能力提供了新的路径。 结论 多孔钽在修复骨缺损方面具有独特优势，但仍需在材料制备及表面修饰方面有进一步突破。

Objective To review the basical research progress of porous tantalum in bone tissue engineering. Methods The related basical research in fabrication, cytobiology, and surface modification of porous tantalum was reviewed and analyzed. Results The outstanding physiochemical properties of porous tantalum granted its excellent performance in biocompatibility and osteointegration, as well as promoting cartilage and tendon tissue restoration. However, the clinical utilization of porous tantalum is somehow greatly limited by the complex and rigid commercial fabrication methods and extraordinary high cost. Along with the publication of novel fabrication and surface modification technology, the application of porous tantalum will be more extensive, the promotion in bone tissue regeneration will be more prominent. Conclusion Porous tantalum has advantage in bone defect restoration, and significant breakthrough technology is needed in fabrication methods and surface modification.

关键词: 多孔钽; 骨组织工程; 骨整合; 表面修饰

Key words: Porous tantalum; bone tissue enginnering; osteointegration; surface modification

引用本文： 丁孝权, 刘兴旺, 陈俊, 陈世益. 多孔钽在骨组织工程中的研究进展. 中国修复重建外科杂志, 2018, 32(6): 753-757. doi: 10.7507/1002-1892.201711040 复制

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